I just joined and found this thread. I shoot a Sig SHR .30-06, factory stock, trigger & bedding, 22" barrel. I load 57.3 grains of IMR 4350 with the 165 gr. SST @ 2900 fps. My groups are .40" at 100 yards and 1.20" at 300 yards (actual). I shot one deer (doe, approx. 190#) at 175 yards (4785' elevation) - my first bang-flop! I hit her between the spine and the shoulder and never found the bullet or fragments. The exit would was slightly larger than the entry.
I use the 180 Interbond for elk with great success, but only group about .750" at 100 yards and 2.4" at 300. I just loaded some 180 SST for better flight path in a cross wind (the 165 is a bit cross wind intolerant). The 180 SST is 57.6 grains of RL-17 and I'm getting 2694 fps from the chrony, with groups of .60" at 100 yards (6009' elevation).
I think the SST is a bit thin-skinned for large game, but devastating on deer and hogs.