I was doing some load development this morning with my T/C Encore 22-250AI and had my first case separation in over 35 years of reloading. Brass was twice fired Lapua 22-250 Rem. Load was 40.0 grains of a Varget which Nosler lists as their max load for a 52 grain bullet. I worked up to this load starting at 37.0 grains and saw no pressure signs. Speed was 3,983 from a 26” barrel. Brass was annealed and full length resized with .002 shoulder setback. I checked the remaining brass with a paper clip and felt nothing inside the case that would indicate this is anything other than an isolated instance. Interested in your thoughts.