Even one night at the trailhead will help. Don’t ascend too quickly. Here’s what I wrote in an article that I never ended up getting published based on the current research: (AMS stands for acute mountain sickness which is the medical termI appreciate your feedback and first hand experiences. I'd certainly love the 3 day period, but don't see anyway it's going to be possible without giving up 3 days of the season. All of us are coming from lower altitude so I'm sure no one will be pushing all that hard the first day or two. On the other hand we are all FBI swat or military, so I suspect our egos will want to see who can out do each other. Haha.
Other than medication, this is the single most important consideration for preventing AMS. It takes our kidneys about 48 hours to fully compensate for dramatic changes in altitude. The majority of this happens as we sleep. The faster you climb altitude, and the higher you end up going,the greater your chance is of failing to compensate and starting a vicious cycle. Current wilderness medicine recommendations are as follows: Give yourself two days to arrive at altitude above 9800 feet. That could mean spending a night at the trailhead, then spending another night on the trail before heading above 9800. If that is not possible, even just one night at the trailhead will help! Do not ascend more than 1600 feet elevation per day. This one is easily broken, but if you are worried about getting altitude sickness then take it slow on your way into camp. If ascending more than 3200 total feet, give yourself an extra day to acclimate before going higher. For instance, if you start at 7000 feet and set up camp at 10,200 feet, you need to rest and acclimate for two days before checking out the next basin at 11,000 feet.