I think QL's the way to go also, fireroad. I have not actually used it but I have had the opportunity to utilize the data it generates. I have heard, however, of a few instances where the predictions were not 100% reliable. I think that's just the nature of our game, though as we are responsible for each of our own safety and have to stay on our toes.
About that Re22 in a .280 Remington, though...I've been down that road myself. I've seen astounding results using Re22, but that powder is, unfortunately, pretty temperature sensitive. With temperature sensitivity in mind, I've tried Ramshot Hunter and found that it burns too fast, Ramshot Magnum burns too slow. I tried H1000 and it was almost right (and just might be the ticket with 160-grain and haevier bullets, but I do not KNOW). I ended up coming back to H4831 and have concluded it is the best powder out there for the .280 Remington. I really wish Ramshot would produce something between Hunter and Magnum, since their powders are spherical they flow through a measure like W296. But for now, nothing beats H4831. It won't lose 100 fps on a 20-degree morning.