Real world experience with a bunch of suppressed precision bolt guns including several 6.5 PRC customs
90% of the time POI shifts 1–2 MOA usually up & right and groups actually tighten a little once the can settles in better barrel harmonics
.
First 15–20 rounds the groups can wander a hair while the can breaks in and carbon builds evenly. After that it's normally same or slightly better than bare brake.
Your handload tuned to the brake will almost always still shoot great just rezero and you're done. Worst I've seen is needing to tweak seating depth 0.005–0.010" to get it back to stupid small.
Temp stability gets better suppressed cooler barrel, so your load usually loves it.
Bottom line: slap the can on, shoot a 20 round fouling/zero string, make a tiny tweak if needed. You'll be back to ringing steel at 1000 with no drama. Most guys end up liking it better suppressed.