I have tested pretty much all of the current rangefinder reticles for an NRA piece a while back. Have not shot the new Leupolds but they are no different than the TDS or Ballistic Mildots. These reticles range from the simple four-bar style to the Horus with about as many bars and intersections as you might care to try counting.
Holdover points are a compromise unless you get Premier Reticle to install custom dots in a Leupold scope for your particular trajectory. That would be the optimum but it also pretty much locks you into using that load only.
I found that the other styles, whether they are bars, hashmarks, diamonds, lines coming from circles or whatever are not as accurate as actually applying the correct elevation and windage required. We are talking extreme accuracy here. They are quicker than clicking tho and work well for hunting.
The holdoff reticles will enable you to kill animals out to the distances you are talking. I believe that the reticle designers have identified groups of bullet/cartridge combinations that have similar trajectories - if the BC is similar and the velocities are reasonably close apparently the bullets will fly in about the same arc. Therefore there are specific loads that work very well with certain reticles spacings. Some manufacturers require that you shoot specific procedures so that you can "categorize" your load to see where it will fit into their bars etc. Regardless, you should shoot any such reticle as much as you can to get familiar and confident.
There are some holdoff reticle patterns that enable simple, accurate shooting. The TDS on one of my .308 Win rifles with Winchester 150 grain Ballistic Silvertips gives me excellent correlation between the bars in one hundred yard increments - 100 is on the crosshair intersection, 200 first bar, 300 second bar, 400 third bar and 500 just a bit low with the fourth bar. Flatter shooting cartridges are frequently 1&200 on the crosshairs, 300 on the first bar, 400 on the second bar, 500 on the third bar and 600 on the fourth bar.
You can do the same thing with mildots, particularly if you vary the power to matchup dots with your poi's downrange. You might require a simple chart that says exactly how much high or low each dot is in 100 yard increments to jog your memory. Don't forget that the mildot reticle is a good holdoff reticle (constant aiming holdoff points).