I use 45.5 grains of H4350, Rem cases, CCI #200 primers, and 80 grain ttsx. Average velocity in my 24" rem 700 is around 3400. I shot a whitetail doe a couple of years ago at 432 yards, the shot was a double lung through the ribs no large bones hit and the wound looked much like what I've seen from a 30-06 at 100 yards.