Simply put…. Up here they appear to be much more nervous/excitable and seem to "overreact" as compared to a Mule Deer given very similar situations!
Our bottomland Whitetails are more nervous than the local Mule deer…..but, not nearly as "nervous" as the Whitetails that I grew up with!
Perhaps not scientific…..merely my experiences! Your mileage may vary!

memtb
The only places I have hunted whitetails extensively have been western Pennsylvania and northwestern Minnesota. It was like I was hunting completely different animals. In PA, the deer are EXTREMELY nervous, at least relative to their counterparts in MN. They also weren't as big - often a full 100 pounds lighter in weight. They seemed to be far tougher when shot. Their nervous and high-strung nature was probably the reason why. The Minnesota deer quite often dropped at the shot, even on rib cage hits. The PA deer usually ran 50 to 100 yards, unless they had been hit through the shoulders. The bullets used didn't seem to matter as much as the deer's temperament when hit. With bullets placed behind the shoulder, it was about 50-50 as to whether or not they would drop right there, but the high shoulder shot knocks them down reliably.
I have never tried the all-copper bullets in either locale - just cup & core factory loads and saboted slugs in 12 gauge. The full-diameter lead Hybred slugs worked better than the 50-cal hourglass-shaped slugs, which were only effective when we hit bones. Otherwise, the holes were too small since they penciled through. The rifle loads I have used varied from 22-250 through 7mm Rem magnum, with most of the kills coming from 308 & 30-06. Bullet size and velocity didn't make a noticeable difference in the outcome - they all worked about the same, including the 22-250. I just don't think that a 150-pound animal is big enough to show any difference in killing effectiveness.
I do know that the bullet I used the most, the 308 & 30-06 Federal Hi-Shock, worked great on everything I have ever shot with it, including elk. It made very large holes on deer, but killed them quite handily. Exit wounds for blood-trailing the lung-shot deer came in handy when there was no snow for follow-up tracking. We often threw away a lot of blood-shot meat, but we always found the deer. Better to lose 5# of shoulder meat than to lose the whole carcass. The 22-250 killed them RIGHT NOW and didn't make a big mess of the meat. I shot about a dozen deer with it, but don't think that's enough of a track record to make a blanket statement that this little cartridge is a better deerslayer than a more conventional deer cartridge. They might behave differently when shot in the bigger bones with those little bullets.
Since I moved away from whitetail country, I have shot a lot of blacktails with the 30-06 & 280 Remington, most with the Hornady GMX bullets. ALL went right down, with very little meat loss. Most were ribcage shots, although a couple were frontal chest shots. When coming to the rattling horns, that's often the only shot you're gonna get. Fortunately, they are close when you have that shot presentation. I'm almost out of these bullets, and plan to use the CX when these run out. 165-grains for the '06; 139's for the 280. Both should do around 2900 fps muzzle velocity, which has always been enough in the past. If/when I go back east for whitetails, I'll take one of those two rifles with me.