The Summer following the SHOT Show when the .30-378 was announced by Weatherby, I worked for Arnold Arms. We rechambered or rebarreled many rifles to that caliber. I cronographed the Norma factory ammo and found it lived up to the hype. It did indeed produce 3400 fps with 180 gr Nosler Partitions. The sad thing was that with the powders of the time, H-1000 and some 50 cal powders we could not achieve the factory performance with handloads. In 2014, Norma marketed the factory powder for this cartridge, Norma 217. That should be an excellent place to start. Nosler 180 partitions are out of style but I will bet that you will achieve the best velocity with Norma 217, Reloader 33 or VhitaVouri N-570.
Have you had your barrel nitrocarburized? It will preserve the throat at least twice as many rounds. Coating your bullets with HBN will also help.