I've have used the 250sst for the past 10 years or more and have never had an issue. I used the barnes one year because the gun I was using only liked them. I shot a doe at 200 yards with the barnes and it only punched a small hole going in and a small hole going out, no expansion . No blood trail and it was behind the front shoulder right where I wanted it to go. I found the deer a week later doing another small drive through the timber. I couldn't find the deer from the week before because we ran 20 to 25 deer through the timber and couldn't get on the trail. The 250sst might explode on impact like some have said however I have not had that issue. It does a good job of tearing stuff up and making sure you have a good blood trail to follow. I would rather have a blood trail to follow than two holes on a deer.
With that all said I believe it all depends on shot placement, every bullet works some prefer barnes over sst or vice versa. IMHO, I don't believe the all coper bullets expand well (unless you prefer high shoulder shots) therefore the sst works better for me. This year I will be pushing them at 2600fps and we will see what they do for me at that speed.
Good luck and remember it is about shot placement.