I've killed and watched killed dozens of critters from blackbuck, coues deer, ky and tx whitetail, axis deer, hogs, and even a red stag with various Amax and ELDM bullets. Never, ever seen an Amax or ELDM pencil through an animal. I've read the stories on here from elk hunters running the 225ELDM and 285ELDM and having splashy, shallow expansion on elk but my two elk were archery and muzzy.
My experience has been with 75gr .224 ELDM, 140gr 6.5 Amax, 140gr 6.5 ELDM, 162gr 7mm ELDM, 168gr .308 Amax and 178gr .308ELDM--- all running 2700-3000fps MV and from 65-350 yards. I've seen very consistent results with great expansion, nothing explosive but they do seem to lose a good bit of weight during expansion especially if you run one through a shoulder blade or rib. However- they always do a great job wrecking vitals and putting animals down quickly.
I would be hesitant to run an ELDM or Amax on elk or other large game. The Red Stag was a target of opportunity and I only had a .308win/168amax with me-- one shot and he barely flinched, slowly turned around to run, stopped, wobbled and tipped over. Not an ideal combo, but it slipped through the ribs and took out the lungs completely.
My sample size for other bullets is smaller-- close to a dozen animals with Barnes LRX 145gr 7mm and 250gr .338, some deer with 6mm bergers, an aoudad and large hog with a 131 blackjack (worked great) and tried some 75gr BTHP that performed terribly IMO.
Based off my experiences I'll continue to use Hornady bullets and I've settled on a 270ELDX for my 338RUM for large, thick skinned game and a 7saum with 162ELDM for deer and below.