I have one in a Rem 700 duracoated and pillar bedded into an LSS stock. It will shoot under an inch at 200 yds if I do my part with the Nosler 225 gr Accubond moly coated clocking 3050 fps out of the 26" ported factory tube.
I've taken one bull elk with it at 320 yds, shattered the offside shoulder. I have also taken two whitetail deer at around 75 yds apiece. Both hit the dirt immediately. My load is certainly not max and I would think that one could achieve close to the same velocity with the recently introduced 250 gr Nosler Accubond.
I would not hesitate to take this rifle anywhere in North America for any game animal. It is one of my favorite rifles.