Nah, they're within a minute of vitals to way out there. You need different turrets for a 5-7K elevation change if you want to dial on the 5 for 500 yds, alternately you can test them at the different place and dial 450 for 500 yds. for eg. Temp & weather doesn't make much difference in a hunting scenario so much as significant elevation change. Leopold told friend of mine (he has VX6 HD and that scope comes with a free custom turret if you want one) since he hunts Texas Hill country mostly elevation of 2000 then out in Colorado a good bit too at 8K, just send in velocity, BC and use 4500 as standard elevation. That seemed a bit sloppy to me but hey, they're the engineers. And turns out the dials are pretty close at both locations...so there's that.