I've been shooting Rem. Model 721 w/24" bbl in 280 Rem. for about 30 yrs., and yes you can get to 2900 fps, but your brass will suffer. Reuse will be no more than about 2-3 times, and check for pressure signs on bolt face/primers. I have used the Sierra 160 gr. BTSP and Nosler 160 gr. Partitions with good results over 54.6 gr. of IMR 4350 and a Large Rifle Magnum Primer (CCI or R-P). This pushes out at about 2800, and out of my gun shoots sub MOA (best 5 shot group ever was 0.324" at 100 yds. with the Sierras). At 250, Sierras about 1" and Noslers about 1.5".
I looked at the newer powders and just haven't seen the need to go there yet. That extra 150-200 fps m.v. isn't going to change the point of impact significantly until you get way past the range I'm comfortable with and capable of seeing clearly thru bifocals.
Be safe