The effective range of a 22-250 depends on the shooter and not the gun, if you are just shooting coyote's then I would sight in for three hundred yards as MPBR, not the 200 yds that someone else suggested, your bullet drop at 400 should be around to 12.4 at 500yds it would be 37.8 inches, at 100 yds you will be 3.1 inches high and at 200yds you will be 4.2 inches high, you must handload but you did not say that you do shooting a heavier bullet would increase your effective range on coyotes, also there would be less wind drift with a heavier bullet, also a Timmey or Canjar trigger would help out alot that is what I have on my Remington 22-250 and a BSA 6x24x50 scope, shoot under a dime at 100 yad five shot group using a 50 grain bullet, " The better you can see the better you can shoot", with that scope I have shot groups under 2 inches at 400yds