I’ve shot two cows with a 6.5CM. Both with the 124 Hammer Hunter (have since went to the 123 Absolute Hammer at 3k fps).
One cow was 275, pass through. The other was 125, fronts shot. Bullet didn’t exit, I didn’t look for it. She was a true DRT.
Even as accurate as my 6.5 is (Kimber Hunter...