I'd love to do a 6.5-06 AI. Stoked with 130g AB or 140g VLD or AMAX, it would make a great LR deer hunting/target cartridge.
I already own a 7 RM, so doing a 280 AI doesn't really do me any good. However a 168g VLD at or near 3000fps is a dandy LR performer out to 1K.
Dont really think you can make an EDGE into a lightweight mountain rifle that you'd wanna pack up and down canyons all day. It is a dandy caliber though when matched with the 300g SMK. My 338 EDGE is one of the lighter ones that Shawn has built and it still weighs about 12.5-13 lbs w/scope, sling, bipod, scope level, ACI indicator, shells and everything else on it.
What animals are you intending to hunt? I assume deer and elk. That would play a major role in deciding which caliber you want. If elk is in the equation I would go no lower then .284" bore.