The short barrel will hurt velocity. My 22-250 has a 28" Shilen. I chronoed a load yesterday with the Hornady 60 grain V-Max and the Superformance powder. I will not even post the velocity because my hunting friends think I am lying. My cousin was with me so I had a witness. This rifle smokes 220 Swifts with the long barrel. You still have a great gun there and accuracy should be fine. A coyote will not get up and tell you that you need more speed. Some fur loads work better at reduced velocities. PM me if you would like load info for that caliber. I have shot them for years.
Good luck, Kirk