Years ago I "needed" a dedicated varmint rifle. Being broke, I couldn't afford anything but a Ruger 77 tang safety, bull barrel. Bought on payments. Loaded 55 grain Sierras because bigger is better. Shot nice groups and I killed a lot of coyotes with that load. Ran out 55 grainers and loaded some 50 grain Sierras. As I shot the group, I was cussing the wasted time and powder because I thought I was missing the paper. When I finished shooting ten rounds I went down range to collect the target. All ten rounds in one hole. Since then I am a little more inclined to try different weights of bullets.
Six years ago I had some extra money laying around and had the Ruger rebarreled. Broughton heavy varmint with an 1:8 twist. Doesn't matter what powder, 70 grain Bergers into one hole all day long.
Had a friend that had pancreatic cancer. He called me knowing my love for the 22-250. Said he had a Browning 78 with a Leupold 12x scope and Canjar set trigger that he would let go for $300.00. I had work pretty hard to find the money but I own that rifle and it shoots lights out.
There might be newer calibers in newer rifles but for my money and my shooting, there is nothing like the classic, tested in time and accuracy of the 22-250.
Did I mention that I have killed many deer with this caliber? Not what I would consider a premier deer cartridge, but doe a credible job with proper bullet placement and the correct bullet, plenty of gun for deer to two - three hundred yards.