I would gather the biggest problem is lack of bullets sold and labeled deer bullets or ammo. Unless you know match and varmint ammo isn't designed for deer what do you chose? Most people who bought 223 ammo for deer hunting bought it for a youth or new hunter. Most had no idea bullets mattered. As long as their green box 270 said 130 grain it worked! No so with 22 cal . You can't go to many stores and buy 22 cal partitions In loaded ammo. There's several "good" .224 bullets for deer size game. Most of them are a hand load only option. Anything labeled varmint or match isn't going to be a good choice. If it has game king, partition , tsx or interlock type words it should work fine