I have been killing deer with a 25-06 for about 30 years. I have shot more IMR and Accurate 4350 with 115 to 120 gr bullets than any powder. My main load is 49 gr of either one of these 4350s, Rem case, CCI 250 primer, 117 Sierra Pro Hunter and it does 3000 fps from my 26" Shilen barrel. I don't shoot deer much over 500 yards because of energy drop off. I have killed a few hundred deer with this combo and never really needed more velocity within my self imposed max yardage. H4350 should work just as good but the load will be a little different. I had another 25-06 that preferred H4831 and it also averaged 3000 fps with the most accurate load, 52 grs, but it had a 24" barrel. As a deer size game caliber the 25-06 is one heck of a drop them in their tracks killer that many have overlooked.