I shoot 45 grains of Varget behind a 175 hunting VLD touching the lands with a BR-2 primer in Lapua brass, shoots great in my 26" barrel as well as my friend's 20" barrel.
The charge is listed in the Hodgdon manual as the maximum charge so use caution and judgment during load development and use reduced starting loads. Also differences in case thickness can cause overpressure if you aren't careful if you intend to use the military brass as well as Lapua.
While I was developing my load accuracy was great in both rifles from 44 grains to 45 grains, so I would say that this combo is pretty forgiving as far as finding the sweet spot.
I haven't played with the seating depth because I don't care if I have to single feed, but according to Berger often you can find accuracy over .100" off the lands.
In the rifles that I am loading this load for I am seeing consistent .5 MOA groups out to 500 which I consider satisfactory considering they are factory Remington barreled actions.