I have always found this question to be interesting when it comes up. If you had to have one rifle and one cartridge combo what would it be? Game ranging from coyotes, whitetail, muleys, elk, bear, moose, and everything else in between. Your ranges are out to 800yds or so or wherever you feel comfortable with your combination. If you reload than your options are pretty much limitless, so the whole "can't go to Wal-Mart and get shells for" statement doesn't apply. If you don't reload than this statement does matter. This isn't just all long range hunting either, kind of like a survival situation where you're living off of your skills and equipment so close range under 200yd shots are possible while long range 600+ shots are equally encountered. So in all, whats your do all be all choice for rifle and cartridge combo that you have to rely on for all sorts of game from ranges point blank to where you feel comfortable. Looking forward to what everyone has to say!