I calculate Maximum Pointblank Range for the given cartridge/bullet/muzzle velocity which for my rifles (7-08, 30-06, 6.5X55) typically puts zero at 300 yards and MPR at around 350yards. I don't currently own a range finder but can use my scope reticules to estimate range out to 600yards. I'm limited to shorter relative ranges by my lack of a rangefinder but this zero lets me hold on hair to 400yds, 1/4 deer high at 450yds, 1/2 deer high at 500yds which I won't shoot beyond. For most here this doesn't qualify as long range hunting, but I don't specifically seek out situations that demand long shots but at the same time want to be able to confidently take an ethical shot if closing the distance is not an option.
The vast majority of animals I've take have been at 100yds or less. I've hunted with guys who use 100yd zero and depend on their rangefinder to calculate where to dial the scope to and have watched them miss opportunities at filling tags when they lacked the time to range the animal and make scope adjustments.
I guess it really depends on your hunting style. Are you going to specifically put yourself in a long range situation? Then I say use 100yd zero combined with range finder and exposed turret type scope to dial in your range.
I'm hoping for a Leica 1200 LRF from Santa this year. I doubt it will change the way I hunt, but I did borrow a range finder this year from a friend and found it a useful tool and gave me confidence when it came time for the shot.
Good hunting.