Your scope and rail (mounts) will be a limiting factor to compensate for bullet drop. If (average) your scope allows for 30 mil elevation, that will only give you 15 mil of adjustment, roughly up if zeroed in the middle of the capability.
At 100 yds (Standard velocity vs high velocity) you will need 5-7 mils respectively.
At 200 yds, you will need 20-27 mils.
At 300 yds, 40-50 mils std vs H.V., so 200 is going to be about the limit on a regular scope and mount setup.
There are lots of folks that shoot to 300 yds and beyond. Heck, there are videos out there with guys shooting 5-600 yds with the .22 L.R. Wind will kill ya on those little 40 grain pills though.
Premium ammo and the "right" ammo helps, but .22 ammo is manufactured very inconsistantly, which makes consistant long range shots difficult, even with premium ammo. Serious folks buy their ammo out of a single lot to help rectify some of those issues.