I am loading for two different 280 Rem rifles. My son uses a Ruger 77 Mark II to shoot deer. He has taken 4 deer with this rifle and the load his gun likes is a Nosler 140 Accubond and RL-19 powder in Remington case, and WLR primers.
I followed the Nosler #6 Manual to develop this load. I worked up to the max listed 57. grains of RL-19. This load also works well in my Rem 700 CDL in 280 Rem. . This load gives just over 2900 ft/sec in my 24 inch barrel and just under 2900 in my son's Ruger.
This is an outstanding load for taking deer.