Hey Echo
Alucard pretty much nailed it. If you going to shoot factory, yup- the 22/250 cant be beat. Ammo is cheaper, easier to find, and there is a greater varity. Plus factory 22/250 beats most of the 220 Swift factory stuff in velocity. BUT if you are going to reload as Alucard said, I too give the nod to the Swift. Now hey, we only talking about a couple of hundred feet per second, OK? But I have shot or seen shot prairie dogs with the 17 Rem, the 204 Ruger, the 223 Rem, and the 22/250 and the Swift. All in the same day. Now let me tell you something. The 17 centerfire, the 204, and the 223 will kill them dead. Some right now, and some, well, some make it to their holes. Hit one with the 250 or the Swift, and it will rain pieces of pasture poodle for 5 minutes. Expecially the Swift. And hardly any hold over compared to some of the others too. Now I like to shoot them with that CZ 527 17 Reminton if i can, because that will do it to them real quick. But I paid and extra $160 for a Vais muzzle break on my Kreiger barreled Swift just so I could watch them pop. And they pop faster than cherries on prom night. Give them the swift, and you be just like that old beer commercial:"Man! It dont get any better than this!