I started with a .308 Win for my varmint and deer needs for LRH. I found that 1000 yards even for ghogs was a little difficult with just enough snot to get us there. We hit around them, but just couldn't get on them. I've upgraded to a 300WSM. With the .308 for deer it runs out of steam at about 800 yards (even then a well placed shot is required with good conditions), with the 300 I can get out to about 1200. My MOA clicks for the .308 at 1000 is 43MOA, w/ the 300 it is split in half shooting 26MOA.
The .308 is really limited to 168-175grn projectiles for the best effectiveness for those ranges. You can use the 110 V-Max for varmints out to about 400. A better marksman than me could push that I'm sure. With the 300 I use a 200grn SMK that will do all my work from short to long, because I generally carry one rifle for varmint. Very few of our shots have been under 200yrds. I guess I like the wind bucking ability, and with the break, recoil is very managable. I will carry the .308 if I know we are shooting short feilds (400 or less).
I think big calibers are very capable of great accuracy.
Tank