High shoulder shot for me. I want them to go down. I know heart and lung shots are terminal but a whitetail can travel 30-45 seconds after these parts are blown out. They seem to go to the thickest, nastiest stuff they can find to expire and there are some cut-downs, thickets and bays around here that you have to machete your way in and out of, plus moccasin's, copperheads and rattlesnakes.
If the deer is close enough, I have a solid rest, and it's to fill the freezer, I'll shoot it in the head. Messy but highly effective.