To me the primer is the most mysterious and important thing in loading accurate ammo.
I had a lot of problems with groups and could not really know what was going on from the 19 60's till 2004. In 2004 my brother and I was getting ready to go on our first trip to Canada moose hunting. My brother was having problems with his Rem. 700 338 WM about 1 in 5 would go about 4" low right out of a less than 1" group. We was at a range one day checking our rifles. Another shooter was there with a new Chroney Chronograph. When he got through shooting his rifle he asked if we wanted to Chronograph our loads. I told my brother go for it. He started shooting a group over the chronograph about the 3rd or 4th shot done its 4" low right thing. This load was shooting around 2970 fps, This low right shot showed 2791 then went back to around 2970. The primers were CCI 250. Went to Win LR and the flier disappeared.
I have a Rem 700 Varmit Barreled H&S stocked 223 Rem. that will shoot near 1 hole groups with a brick of Rem SR primers I have, CCI Bench rest or WW primers makes the group go to 1" or better.
About 2 months ago my buddy received his 7mm/08 Rem. from NULA. He started loads with Winchester LR., The groups was running near I 1/2". The chronograph was showing about 90 FPS var. in velocity. He changed to Federal Gold Medal 210, Shot groups in touching clover leafs .375", Only 13 foot variance through chronograph.
Any time I am working up loads, Change primers or primer lots, I will not go to the range without my chronograph going with me.