My longest shot to date with a 22-250 happened last weekend. It's a stock 1-12 twist CZ 550 heavy laminate that I'm shooting plain Jane 50gr Sierra Spitzers out of. Popped a groundhog at 586 yds with it. With this bullet, I would guess I could reach a little farther, say to 700, but not much more than that. I've ranged a particular groundhog at just under 750, but haven't taken a shot at him yet. Hopefully, this weekend he'll give me an opportunity and I'll have some good news for you.