I know it's old, but I simply HAVE to chime in on this thread, after seeing it. The reason being is that (how do I say this without it not sounding right?), I like to "go around" thinking that it is ME, who is the undisputed #1 fan of these rounds, in this weight and caliber. But let's see if THAT statement opens up any "disputes".
Anyways, it is my belief (and experience) that the faster you launch 'em, the better they work. I used to send them out at 35 to 36 hundred fps with the rem mag barrel. But now with ultra mag power behind them, the fps #'s are near 4K. There is really no question as to whether or not they will take big game down cleanly. But it all depends on how you define "cleanly". If bone is struck on the way in, things might not be looking very clean, once you get into the butchering stage. But even when that happens, they still "drop" just as cleanly, when the shot is taken.
As far as range is concerned, they should be good for up to 4 digits, when driven at that kind of velocity. At lower velocities, wind drift would be more of an issue, of course.