Over the years shooting F-class, I have found that seating depth tests take precedence over charge weight.
I can try a new bullet, do a seating depth test with a middle load of a suitable powder that will most likely be one I use for the final result and, that seating depth test result stays the same throughout testing and final result.
Seating depth rarely, if ever, changes throughout a barrels life. As the throat erodes, increasing the velocity back to the original velocity keeps the bullet in the node, minor seating changes may be necessary. I get 3 set-backs per barrel and they last in excess of 3000 rounds for me….this is not something you can do with a hunting rifle, but the throat erosion is real and powder adjustments will be necessary to compensate.
Cheers.