I've been thinking about this same thing myself. I got a pretty little Savage 114 in .270 Win in a trade and even though the barrel is only 22" the dang thing is accurate, beyond what I expected! All my other rifles are anywhere from 10lbs up to 15lbs w/scopes, so this little 8lb Savage is a joy to hunt with and I find myself toting it more and more. Kicks right smart though.
Anyway, the other day I was pondering what I could re-barrel it to once I couldn't control "that itch" for something new anymore. I currently have a 6mmBR, 6.5-284, this .270Win, 7mmRM, .300WinMag and a .270 Allen Magnum. In keeping with the .473" bolt face, I have always wanted the 6.5-06AI, .270AI but the Sherman versions outpace both of these rounds. Brass prep would probably be about the same either way. Brass for any of these aught 6 spawn is plentiful. Just depends on your favorite flavor.
Not sure if the brass is available yet or if it is, what's the cost, but Weatherby's 6.5 RPM with a 28" tube/and break, launching the Berger 156's would be would awesome!