22 Creed is very difficult to find dies for right now. The 22/250 AI is the kissing cousin of the 22 Creed, and it does not stink in terms of accuracy, speed, with brass and dies available.
I have been hunting coyotes for a long time. I have used a lot of sub calibers from 17 AH, 17 Mach 4, half a dozen factory and custom 17 Rem's. At that same time, I was also running 22/250's and custom 243's. Later on, I settled on a 22/250 AI shooting the 55g Sierra's and Ballistic Tips at 4050 fps and 60g Berger match HP at 3700 fps with Win 760. Later on, I had a custom 6 Rem shooting the 80g at 3500, then had a switch barrel added with 6 Rem AI shooting the 70g Noslers at 4100 and 80g at 3800.
I don't save pelts, and I don't like to see a coyote run off after getting hit on quartering shots.
Recently, a group of us found a very effective Bolt gun load only, for Rem 700's with the 55g Sierra Blitz lead tip shooting a load Hot load of XBR 8208, CCI 450 into very tiny groups at 3470 fps in 24" rem factory rifles. The 55g Sierra lead tip blitz bullet just massacres large coyotes from all angles, and we have a lot of large coy dogs in our area that are from a Red Wolf Mix.
I like to be able to hit a coyote behind the diaphragm on a trotting shot where he will be laying in his tracks.
Use enough gun, and I do not count on making perfect standing shots only.