I've had most of the calibers mentioned at one time or another and recently put together a 6BR for PRS. Seems like a lot of the pros are going to 6BR and 6MM Dasher, etc. You can easily see what's going on down range, no problem shooting to 1000, and very easy to load for. Get some Lapua brass, CCI 450s, 105 Berger Hybrid Targets and Varget. All these items, with the exception of the primers, have been popping up frequently lately.