Jason,
if you install the bases and rings correctly and lap them what you have will work just fine. I've used them for a .30-06, a 7mm Wby magnum and a 270 WSM without a problem. In addition they've been used on thousands of magnum rifles.
However, if you want what I (and many here) think is a better system then swap your Leupold rings for Burris Signature rings. Take a look at the video here; I know it's a lot of advertisement but you get the idea:
Scopes - rings by Burris Optics
As the guy in the video says, you can use the inserts to adjust your initial point of impact to be very, very close to where the bullet is going to hit when you shoot. Using a laser boresighter (and a ballistics program) I can set up a rifle to hit paper at 100 without firing a shot.
Some of the long rangers set it up so that the scope points below the 100 yard POI and they'll have more chance to use the full range of the scope's vertical adjustment.
FYI if you have the rear Leupold mount with the "windage screws" you can use those to adjust your left/right and can then use the inserts to adjust the up/down only. That works much easier.
Oh, and if you get them one of the least expensive places is Optics Planet. Buy the insert kit for $14.99 while you're at it to save yourself from having to order it later.
