Lots of guys run elevation turrets of some sort of ballistic reticle on their scopes. I do a little of both but I also have a 257 Weatherby that will be zeroed at 300 yards for deer next fall. Still have to shoot to verify but at 12X the lower duplex of my reticle should make a handy aiming point for 500 yards and hold pretty much dead on out to 400.
I like to keep the top of my trajectory to about 3 inches. In my two LR rifles, 300 RUM and 25-06, I am getting 3400 fps which allows me to zero @ 300 yds which give me just less than 3" high @ 175 yds. With this zero I can hold on top of back @ 400 or about 2-3 MOA over at 500 yds (or dial). Less than 3300 fps and I zero @ 250 yds.
I zero all of my rifles at 300yds. From 0 to 350, I "play it by ear" and just hold under, dead on, or slightly over. Most bullets starting out with a muzzle velocity of 3000fps + don't drop much out to 350yds. From 350 on out I dial it in. JohnnyK.
I use many ballistic and rangefinding reticles for long-range shooting, and i never sacrifice point blank range to make a reticle an intuitive system (even hundred yd. intervals). I always calculate MPBR conservatively for no more than 3/4ths anticipated tgt. size. The reticle zeros are calcd. and tested usually at the optic's (2FP) highest power.