I have a 6.5x06 which is just about identical case capacity as the PRC. My powder of choice is 53 grs of IMR-4350 with the Barnes 120grTTSX. Primer is the CCI 200 LR. Out of my E.R.Shaw 24" stainless 1/8 twist Bbl I get 3277fps & excellent case life. After a case has been fired 6 times I still have very snug primer pockets so I am definitely not over pressure. Since these cases are very similar in capacity, performancs should also be similar. Yes I reuse my targets a lot. This is a typical 3 shot group at 108 yds & also smacks my target at 522 yds with a good thunk sound back. This bullet & load is a proven elk downer.
6.5 prc is a big rifle with 69gr powder capacity? Mid class in my mind. It's the smallest case out there on 537 case head. Essentially a recreation of the 6.5 rem mag minus the belt. I personally tested cci 250, 215m, 210m br2. And 210m had the best accuracy and lower ES/SD vs the other 3.