It's weight on the barrel, it will change the harmonics. Suppressors do they same thing, and a barrel tuner is based on this principle. There's no way I know of other than shooting to determine the actual impact of the changes. If I'm shooting suppressed, I develop the loads with the suppressor on because groupings do change, not just POI, especially with the heavier cans.
I see an impact shift of about an inch or so at 100 but that doesn’t bother me too much when doing load development. I’m only looking for a speed node and don’t care where or how it groups. But if you do want to shoot groups while checking velocity or if you are shooting a suppressor. Wiser Precision has a carbon fiber rod that allows you to get off the barrel and adapts to a picatinny or arca-swiss rail. Costs about $100, light weight and tool-less. Check it out. https://www.wiserprecision.com/products/chrono-mount