As mentioned, my self and others that have been down this road found that the limiting factor is normally the bullet. you can always neck down a 378 to 22 cal but again the bullets are the problem.
My experiment was with a 223 WSSM and my goal was anything over 4600 ft/sec. 4400 was easy to reach but the bullets were coming apart,
and by the time I reached 4600 ft/sec, I was down to one bullet that shot well. All others including mono metal bullets lost all accuracy around 4200. my barrel had a 1 in 15 twist and after analyzing the problems the jacketed bullets were shedding the jackets and the mono metal bullets were not stable because of poor engraving.
I also tried a 7/STW with a 31'' barrel and everything including accuracy was good until i pushed the 140 grain bullets over 3700 ft/sec. I thought I might be able to push on past that and did manage to reach almost 3900 ft/sec velocity but accuracy only got worse.
After talking to many bullet makers and many good re loaders, the consensus was almost unanimous, the bullets had exceeded their
design limits. and because bigger heaver bullets are designed for lower velocities they cant go as fast as smaller bullets designed for higher velocities. inertia causes the jacket to separate from the core
quicker in the heavier the bullet (More mass to rotate).
Mono metal bullets might solve the problem but only if the right twist was found, but that would require many barrel changes.
What I learned from all of this and per the advice of every bullet maker i spoke with was it was best not to exceed the bullets designed velocity by more than 2 or 300 ft/sec.
There is no laser flat projectile, that doesn't have any drop so looking for it is futile.
Save your self a lot of time and trouble and just build something that will do what you want.
Bin there and done that !!!!
J E CUSTOM