I use a modified version of the MPR (Maximum Poinblank Range) method. Using Sierra Infinity software to determine MPR I round to the nearest zero range, ie for a given rifle and a 10" vitals zone MPR Zero=301yds and MPR=355yds. I then change to the regular trajectory mode and set my zero at 300yds, close enough and easier to verify zero when I go to the range. This lets me not have to consider any holdover until my range is beyond 355yds (beyond where most of my shots have ever come) and I can print out a range card that gives me bullet path clear to 1000yds (600 is sufficient for my skill level) in increments of 50yds. Using data from my range card I sight the rifle in 3.9 inches high at 100yds then verify at 300 and go hunting knowing I don't have to worry about hold over at any normal ranges but armed with the knowledge to shoot a little further if needed. What do you do?