fps needed to kill a Mountain Lion at close range??

I second Dan B.'s idea except use a larger caliber pistol. Something like a .41 Mag or .44 Mag with a hard cast bullet like an LBT design. They have a large meplat which is what really dictates the killing power, but don't mushroom and destroy the pelt. If you tangle with a really big tom, you'll be glad you have the extra bullet diameter and weight.
 
If you have a 22 caliber such as a 22-250, .223, 22 hornet, something that's a tack driver and you have confidence in, I'd suggest an eye shot. I've dropped a lot of Bobcats with a 22 mag through the eye.
 
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