Hate to say it depends but it does. I started by 6.5/06AI with 200 rds of Lapua brass. Got into a bad (really hot) lot of RL22 and did not check it on chrono ahead of time and loosened about 60 primer pockets real fast in one load. However the remaining cases have had about 15 plus loadings in them no problem and I am running 140s at 3050 out of 28" barrel. Going to another lot of brass for this year just on the general principal.
Bottom line it is going to depend on your gun and how you work up the loads. It could range from one to 20 loadings.