I've had a mystery ranch crew crab 7500 for a while but finally got to put it through a real hunt this past September, hiking around with my 16.5 lb edge on the side in the water bottle pocket. Total pack weight was a little over 50lbs and was very comfortable carrying for 3-6 mi a day ascending and dscending 2000 ft. The only other pack I've had was a cheap cabelas pack so not much to compare with. But the MR was built comfortable enough that with my rifle on one side and even if you didn't balance the weight out you really couldn't even tell there was more weight on one shoulder. Yes by the end off the day if you don't switch sides your shoulder will be a little sore. There are also three straps on each side that will cinch the rifle down tight enough to keep the rifle from moving or sliding no matter what your doing.