Great question to ask.
I believe that twist and rifling play a big roll in why some people have both good and bad experiences with the same bullet.
I don't like any more twist than I need to stabilize a bullet for what I'm intending to do with it. So I don't like to "over stabilize" I've found that most bullets accuracy node gets a little tighter when you spin them up really fast. Basically, they get more finicky in fast twist barrels.
Twist rate can drastically affect the terminal ballistics of the bullet. This is probably why so many people have different experiences with the same bullet.
There has been a recent trend to get the fastest twist barrel you can, and in many cases it makes sense to do this. However I'm seeing more and more of this lately, without understanding what it does to the bullet when in hits a critter.
It's not as simple as which bullet to use for which range? You have to consider how your rife shoots that bullet, and velocity isn't enough. I've been guilty of bashing bullets that other's love, but when you remove your opinion and look at the math, there will usually be reason someone loves a bullet that you'd never use. Some of it is probably just luck.
That said, for 20-500, I'd see how your rifle likes the accubond.