Unless you break the shoulders and spine, any deer can run no w matter u shoot them with. First pic.130 grain 270 sst on a 200 lb muley at 235 yards. Boom floop. Destroyed shoulder 2nd picture, mulely shot at 90 yards. 338 lapua 300 grain Berger double lung hit.. Ran 45 yards before hitting a fence. Exit wound size of baseball. All vitals turned to jello. 3rd pic, 180 Berger 7mm mag VLD deer still ran 10 yards. Deer should have never been able to take a step, but did. The main thing is bullet placement and large exit wounds for blood trails if they run.