It will flatten an elk. As will 300 gr. Sierra. I don't shoot factory ammo so I can't say, but I shoot Lapua and Edge, and I shoot the 2 bullets mentioned at everything from squirels and rocks to elk and bears and they both have awesome any range terminal performance!
Just don't use a Lapua bullet for hunting, as they are to hard and will pencil through unless you take a head or spine shot.gun)