In my years of hunting deer and mainly whitetail with a few mulies and 1 elk hunt, I've used lots of different bullets from various manufacturers. Factory and reloads both. Hollow points, spire points, ballkistic tips, flat nose pistol hollow points out of a 357 Herrett, 7mm Rem Mag, 243, 6mm Rem, 30 Herret, 22-250 (accounted for over 100 deer over a 20 year period), and a 30-30. Two things I have always concentrated on were shot placement and knowing my limitations. One thing I have come to know over the years that has no equation or rule of thumb is an animals drive to survive no matter what. Point in case, I use a 300WSM using Berger 215 Hybrid VLDs. Shot a whitetail doe at 100 yards in the heart lung area. The doe ran 90 yards before she plopped over dead. I was stunned in thinking I did not place my shot well and was quite disappointed in myself considering my 40 years experience. When I got to her, 30 cal entry hole, exit hole on offside you could put a baseball in and not touch the sides. Half the heart was hanging out the hole, other half was gone as were 3/4 of her lungs. Tremendous blood loss. The will to survive is incredible in these animals. Bullet failure, nope, shot placement failure nope, will to live - incredible!