It might if everything goes exactly right. Don't go to Africa expecting everything to go exactly right.I agree with snox. The .270 will work with a good solid bullet.
I'm not all that tough and I can say with confidence that my unbraked custom .375 Ruger is one of my all time favorite rifles to shoot.My brother has brought his 375 to Africa 5 times so far and he will be going again with a first time friend in a couple months. He is obviously comfortable with his 375 as am I, up to a point. I would not want to spend an afternoon working up loads while shooting it from a bench, but shooting it a half a dozen times in an outing over the course of a day it is fine. To me it is not a whole lot different than shooting my 338.
Like you said it all boils down to your comfort and confidence level. Learning African animal anatomy for shot placement is critical. No pocket behind the shoulder shots in Africa, no vitals to hit there.
Good luck to you and enjoy everything you see and ask a lot of questions of your PH.
Beautiful Sable.View attachment 121234 Hi Longest shot:
After reading most all the posts and on 4 safari's in Africa I would recommend the A frame or Partitions in the heaviest weight your rifle will shoot with good groups they just work. Also a 15 to 25 lighter grained load for the smaller game that prints almost the same. I also now take 2 rifles that I am so comfortable practicing with Sticks, kneeling, prone and improvised backpack that I do not notice the difference exchanging them one for the other leaving me with a backup I am super comfortable with and not resorting to a loaner (I had this happen on my first hunt when a stock setback and split out it had to be MacGyvered in the field with hide glue, beer can shims and electrical tape plus drying time) this gives me 40 rounds for each with a light and heavy hitter split between. Remember African animals are tough very very tough compared to North American game their kill zones are also some what different with the forward heart. I personally like to use a Ruger #1 in 3006 with a 26" barrel so almost equal to a win Mag with less recoil and weight. I took a Sable at over 400 meters with a 180 Partition that passed through and broke both shoulders knocking it down like a truck hit it. We thought it had been a perfect shot and started walking to get it, then aprox. 1 minute later that Sable got up an ran off like nothing happened none of that bone had hit the heart. Thanks to my tracker and PH. I have that animal. An Eland is still on my list next hunt but I will be using a 338 win mag or larger there is no replacement for displacement. Also a pocket African game shot placement book is your best friend and a very minor expense I now have 2 one for camp to prepare around the nightly fire and one that stays in my hunting jacket as over there targets of opportunity just happen. Good luck and plan on a lot of walking that Sable took me 15 to 18 kilos over 21 days worth every step that Eland will probably be more they cover ground fast.